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Title Details:
Plasma Cell Dyscrasias. Multiple Myeloma
Authors: Loukopoulos, Dimitris
Reviewer: Konstantopoulos, Konstantinos
Subject: MEDICINE AND HEALTH SCIENCES, LIFE SCIENCES, BIOLOGICAL SCIENCES > HEALTH SCIENCES > MEDICINE > CLINICAL MEDICINE
MEDICINE AND HEALTH SCIENCES, LIFE SCIENCES, BIOLOGICAL SCIENCES > HEALTH SCIENCES
MEDICINE AND HEALTH SCIENCES, LIFE SCIENCES, BIOLOGICAL SCIENCES > HEALTH SCIENCES > MEDICINE > PATHOLOGY
MEDICINE AND HEALTH SCIENCES, LIFE SCIENCES, BIOLOGICAL SCIENCES > HEALTH SCIENCES > MEDICINE > PUBLIC HEALTH > PREVENTIVE MEDICINE
Description:
Abstract:
Multiple Myeloma is a plasmacytic neoplasia resulting from an unjustified, unnecessary and uncontrollable proliferation of one clone of plasmacytes in the marrow (rarely elsewhere) with the following consequences : (a) inhibition of the growth of the other cell series (hence anemia and thrombocytopenia), (b) bone destruction (osteoporosis, osteolytic lesions and hypercalcemia), (c) an increase of the monoclonal immunoglobulin in the plasma in association with the expected hyperviscosity and disturbed microcirculation, (d) progressive renal deterioration mainly due to the abundant excretion of free light chains (Bence Jones proteins), and (e) a decrease of normal immunoglobulins leading to increased susceptibility to infection. All of the above appear in various combinations and degrees of severity. The diagnosis is based on an array of morphological, caryotypic, biochemical and molecular parameters; the latter are also offering a certain insight into the underlying pathogenetic mechanisms. Therapy is complex but effective as a rule; it comprises cytostatics, immunomodulators and targeted medications, as well as autologous stem cell transplantation following megatherapy.
Linguistic Editors: Klada, Nektaria
Graphic Editors: Papakosmas, Ioannis
Type: Chapter
Creation Date: 2015
Item Details:
License: http://creativecommons.org/licenses/by-nc-sa/3.0/gr
Handle http://hdl.handle.net/11419/3086
Bibliographic Reference: Loukopoulos, D. (2015). Plasma Cell Dyscrasias. Multiple Myeloma [Chapter]. In Loukopoulos, D., & Politi, M. 2015. Hematology lessons [Undergraduate textbook]. Kallipos, Open Academic Editions. https://hdl.handle.net/11419/3086
Language: Greek
Is Part of: Hematology lessons
Number of pages 13
Publication Origin: Kallipos, Open Academic Editions