Title Details: | |
Hemoglobin diseases |
|
Other Titles: |
From molecular biology to clinical management |
Authors: |
Loukopoulos, Dimitris Traeger-Synodinos, Joanne Makis, Alexandros |
Subject: | MEDICINE AND HEALTH SCIENCES, LIFE SCIENCES, BIOLOGICAL SCIENCES > LIFE SCIENCES > MOLECULAR BIOSCIENCES MEDICINE AND HEALTH SCIENCES, LIFE SCIENCES, BIOLOGICAL SCIENCES > LIFE SCIENCES > MOLECULAR BIOSCIENCES > GENETICS MEDICINE AND HEALTH SCIENCES, LIFE SCIENCES, BIOLOGICAL SCIENCES > LIFE SCIENCES > FUCTIONAL AND ORGANISMIC BIOLOGY > PHYSIOLOGY > PATHOLOGICAL PHYSIOLOGY MEDICINE AND HEALTH SCIENCES, LIFE SCIENCES, BIOLOGICAL SCIENCES > HEALTH SCIENCES > MEDICINE > CLINICAL MEDICINE MEDICINE AND HEALTH SCIENCES, LIFE SCIENCES, BIOLOGICAL SCIENCES > HEALTH SCIENCES > MEDICINE > INTERNAL MEDICINE > HEMATOLOGY MEDICINE AND HEALTH SCIENCES, LIFE SCIENCES, BIOLOGICAL SCIENCES > HEALTH SCIENCES > MEDICINE > PATHOLOGY > CLINICAL PATHOLOGY MEDICINE AND HEALTH SCIENCES, LIFE SCIENCES, BIOLOGICAL SCIENCES > HEALTH SCIENCES > MEDICINE > PATHOLOGY > MOLECULAR PATHOLOGY |
Keywords: |
Hemoglobin
structure and function genes transcription and translation Mutations and gene deletions a- and β-thalassemias sickle cell disease novel therapeutic approaches. |
Description: | |
Abstract: |
Hemoglobin is the red protein of erythrocytes which, through its highly specialized structure, transports the oxygen of the air from the lungs to the tissues and organs.Each hemoglobin molecule consists of two α- and 2 non-α chains. The information for the synthesis of hemoglobin is contained in the respective genes. There are different types of hemoglobin. The globin genes can suffer various damages that bring about either a reduction in synthesis or various variations of its structure accompanied by new properties, often harmful to the organism.These situations are important both for the patients and for the Health Service Delivery System. Consequently, they are an important chapter in the Medical Curriculum. The proposed book is intended to assist in the teaching of hemoglobinopathies by systematically covering in 15 chapters (a) the structure and function of the various types of hemoglobin, (b) the genes that direct its synthesis, and (c) the molecular disorders that result in morbid situations (Chapters 1-3). In the following chapters, the pathophysiology and the clinical picture that characterizes each of them are described in detail. In particular, chapters 4-10 deal with the thalassemias, where the damage results in a reduction of α- or β-chains resulting in severe, chronic and incurable anemia, while chapters 11-14 cover sickle cell disease, another severe hemoglobinopathy characterized by unbearable pain for life. Each set includes information about the symptoms and findings of the respective pathological conditions, the imposed conventional treatment, as well as the efforts made for radical treatment utilizing recent technological advances. Finally, chapter 15 refers to other variations of hemoglobin, which give it strange, sometimes beneficial, sometimes harmful and sometimes indifferent functional properties.
|
Linguistic Editors: |
Iordanidou, Dossy |
Graphic Editors: |
Kentrotis, Christos |
Other contributors: |
Vrettou Christina, special contribution for Chapter 20 |
Type: |
Other kind of textbook |
Creation Date: | 28-01-2024 |
Item Details: | |
ISBN |
978-618-228-192-5 |
License: |
Attribution - NonCommercial - ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
DOI | http://dx.doi.org/10.57713/kallipos-426 |
Handle | http://hdl.handle.net/11419/12288 |
Bibliographic Reference: | Loukopoulos, D., Traeger-Synodinos, J., & Makis, A. (2024). Hemoglobin diseases [Other kind of textbook]. Kallipos, Open Academic Editions. https://dx.doi.org/10.57713/kallipos-426 |
Language: |
Greek |
Consists of: |
1. Hemoglobin – Oxygen Transport 2. Genes and Hemoglobin Synthesis 3. Fetal Hemoglobin. Hemoglobin A2 4. Genetic events leading to disorders of the structure and composition of hemoglobin chains 5. Molecular lesions in β-thalassemia 6. Pathophysiology of β-thalassemia 7. Iron as a tertiary modifying factor in β-thalassemia. Relation of iron absorption to inefficient erythropoiesis 8. b-Thalassemias. Epidemiology and classification 9. Laboratory findings. Diagnosis 10. Clinical Manifestations and progression in transfusion dependent thalassemia major (TDT) 11. Clinical Manifestations and Progression in Non-Transfusion Dependent Thalassemia (NTDT) β-Thalassemia 12. Treatment 13. a-Thalassemias 14. Hematological findings and clinical manifestations in α-thalassemia 15. Structural hemoglobinopathies 16. Sickle Cell Disease, general information and definitions 17. Pathophysiology of sickle cell disease 18. Clinical findings in sickle cell disease 19. Troubleshooting – General problems 20. Techniques for the study of hemoglobinopathies |
Number of pages |
278 |
Publication Origin: |
Kallipos, Open Academic Editions |
User comments | |
There are no published comments available! | |